❄ Nicotine Salts™ "SIGNATURE™" 100mg/mL ❄ USP Pharma


This nicotine product is intended for use in oral/dermal nootropic, laboratory research, & nicotine replacement therapy (NRT) formulations ONLY. This includes, but is not limited to: gum, lozenges, transdermal patches, oral sprays, inhalers. This product is NOT intended for use in electronic cigarettes, vaporizers or any vaping application.


Now available in 120mL - 1L sizes! FIFO - Freeze in, First out - is Nude Nicotine's new on-demand shipping option! We have a select amount of SKU that are kept in-stock in our -20C freezer system for immediate retrieval and shipping. Instead of the traditional Nude Nicotine method of manufacture-to-order, we now have the option to ship immediately without lead-time! Freeze in First out orders are selectively shipped first and foremost, with a maximum 48 hour wait time from order-placed to out-the-door. 

If your order is placed before 8:00 am (PST) on Mon-Thurs, it will be processed and shipped by the next day!

(All orders placed after 8:00 am (PST) Friday will be processed and shipped on the following Monday)

“Signature” Nicotine Salts solution is one of our three Nicotine Salts formulations designed around harnessing the differing properties of nicotine inhalation character. “Signature” utilizes a blend of multiple cations in exacting proportions to that of the tobacco leaf. “Signature” is a singular focus of our knowledge in X-Ray Crystallography on the cationic acid-bound-nicotine complexes on the tobacco leaf. If there is a formulation on the market emulating the EXACTING inhalation/exhale characteristics of tobacco leaf nicotine, this it it. “Signature” is a combination of the two characteristics of both other formulations, “Hit” and “Smooth.” While “Hit” focused on nicotines ability to “bite” the back of the throat, “Smooth” focused on binding nicotines basic nitrogen centers to “smoothen” the bit of the inhale, along with masking harness of the exhale. These two characteristics were the polar opposite ends of the spectrum of nicotine inhalation/exhalation character, and as you guessed, “Signature is a solid combination of both characteristics with tobacco-specific origins. Numerous cationic acids exist on the tobacco leaf; we know this since the pH of tobacco smoke is closer to 5 on the pH scale (1-14) than that of the basic nicotine, which is closer to 8. These acids possess positive charges, AKA free hydrogens, with exhibit attraction to nicotine’s basic nitrogen centers. This is nature’s beautiful way of stabilizing the nicotine molecule for prolonged activity and defense against oxidative degradation. The binding of cationic salts at nicotine’s electronegative nitrogens prolongs the oxidative damage it may suffer in comparison to a non-salt formulation! X-Ray Crystallography and other data from literature was aggregated in-lieu of traditional GC/MS or LC/MS reports due to the weaker binding forces that hold these cationic-anionic pairs together. Basically, they have to be frozen down to cryogenic temperatures to lock bonds in-place and then analyzed in-situ. This reveals the pairs of nicotine and acid bound together that would normally be separated when solvated into solution! We are able to bind these pairs in-situ at the Nude Nicotine laboratory pre-dilution to achieve this effect. "Signature" Nicotine Salts are formulated at 100mg/mL concentration and diluted in VG, are ready for use immediately. The use of the cationic salts may accelerate the color change of the nicotine salt solution, but is by no means indicative of oxidation therein. The binding of the two molecules results in a sharing of electrons from the cationic salt with the anionic nicotine, resulting in color!!!

Customer Reviews

Based on 6 reviews
Cpt. Kurtz, Ret.
Consistent! Dependable! Perhaps the best!

I always know what I’m buying--and what I’m vaping into my body. This is a great product! Unfortunately, current political dispositions and public temperament want to change the behavior of papers. As long as I can buy this product I don’t think I could find anything better!

Marcus Rice
Nude Nicotine Salts

I was recommend this company quite a few years ago by a high end vaping outlet when nicotine salts were just becoming popular in the UK. I originally ordered a 500 ml bottle of ‘Smooth’ which lasted ages. When I went to order more there was issues with the US shipping so I couldn’t get any replenishment for ages. This forced me to true other brands. Nothing comes close to Nude Nicotine products. I have used the Pharma ‘Smooth, Signature and Hit' all of which are first class. I received the items quickly. I would recommend all of these products and Nude Nicotine. Probably pack up vaping if I couldn’t get their nicotine…


excellent service and product

The only company I buy from

I have tried other brands, they all make me cough and cough.
Nude Nicotine Signature Salts are the only one I use for the past 4 years.
Always smooth with a bit of a throat hit and very satisfying.
Dealing with the company has been a good experience as well, customer service, when needed is prompt and professional. Shipping is always perfect, they seal their bottles so no leaks and packing protects from any other damage.

I am so disappointed with the developments regarding the PACT Act and shipping with the big 3, USPS, FEDEX, UPS.
I don’t know where to turn to get this the next time I need it. Hopefully solutions will come. Until then, thank you so much Nude Nicotine, you have supported me exceptionally well these past 4 years. I just hope I can order again when I need to.
Best of Luck.


superior product, best practices packaging, and professional service